- What is Trental?
- Why is Trental prescribed to patients?
- What are the side effects of Trental?
- What is the dosage for Trental?
- Which drugs or supplements interact with Trental?
- Is Trental safe to use during pregnancy or while breastfeeding?
- What else should I know about Trental?
What is Trental?
Pentoxifylline is an oral drug used for treating symptoms of intermittent claudication caused by peripheral arterial disease (PAD).
Why is Trental prescribed to patients?
Pentoxifylline is used for the treatment of intermittent claudication caused by peripheral arterial disease.
Is Trental available as a generic drug?
Yes
Do I need a prescription for Trental?
Yes
What are the side effects of Trental?
Common adverse effects include:
- nausea,
- vomiting,
- dizziness,
- headache,
- diarrhea,
- blurred vision,
- agitation,
- insomnia and
- drowsiness.
Other side effects include:
- abnormal
- heart beats,
- elevation of
- liver function tests,
- jaundice, and
- hepatitis.
What is the dosage for Trental?
The recommended dose of pentoxifylline is 400 mg three times daily with meals. The dose may be reduced to 400 mg twice daily to reduce adverse effects.
Which drugs or supplements interact with Trental?
Pentoxifylline reduces the breakdown oftheophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin) in the liver, increasing blood levels and side effects of theophylline. Combining pentoxifylline with warfarin (Coumadin) may increase the risk of bleeding. The mechanism for this interaction is unknown.
Is Trental safe to use during pregnancy or while breastfeeding?
Pentoxifylline has not been adequately studied in pregnant women.
Pentoxifylline is excreted in breast milk and may cause adverse effects in the infant.
What else should I know about Trental?
What preparations of Trental are available?
Tablets: 400 mg
How should I keep Trental stored?
Pentoxifylline should be stored at room temperature between 15 C - 30 C (59 F - 86F), in a light resistant container.
How does Trental work?
Peripheral artery disease is caused by the build-up ofcholesterol plaques in arteries of the legs. Plaque blocks arteries, reducing the flow of oxygen-carrying blood through the arteries to the muscles. This causes pain upon walking and reduces mobility. Peripheral artery disease is similar to coronary artery disease in which plaque builds up in heart arteries, causingchest pain (angina) because of a reduced supply of oxygen to the heart's muscle. Pentoxifylline, through unknown mechanisms, decreases the "stickiness" (viscosity) of blood and thereby improves its flow through arteries. This increases the flow of blood and oxygen to muscles and helps patients with intermittent claudication.
When was Trental approved by the FDA?
The FDA approved pentoxifylline in August 1984.
Health News
- Diabetes Can Age Your Brain, But Lifestyle Change Can Reverse That
- Weekend Catch-Up Sleep Could Do Your Heart Good
- Six More Deaths in Listeria Outbreak Tied to Boar's Head Deli Meats
- U.S. Surgeon General Calls Parental Stress an Urgent Public Health Issue
- Evidence Supports Classroom Cellphone Bans
- More Health News »
Summary
Pentoxifylline (Trental, Pentoxil) is a drug that is prescribed to treat of intermittent claudication caused by peripheral artery disease (PAD, PVD, peripheral vascular disease). Side effects, drug interactions, warnings and precautions, and pregnancy safety should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
- Picture of Peripheral Vascular Disease Diabetes also affects the blood vessels and alters the flow of blood. See a picture of Peripheral Vascular Disease and learn more...
Related Disease Conditions
- Fatty Liver Nonalcoholic fatty liver disease or NASH occurs due to the accumulation of abnormal amounts of fat within the liver. Fatty liver most likely caused by obesity and diabetes. Symptoms of fatty liver disease are primarily the complications of cirrhosis of the liver; and may include mental changes, liver cancer, the accumulation of fluid in the body (ascites, edema), and gastrointestinal bleeding. Treatment for fatty liver includes avoiding certain foods and alcohol. Exercise, weight loss, bariatric surgery, and liver transplantation are treatments for fatty liver disease.
- Peripheral Vascular Disease (PVD) Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside the heart and brain. Doctors commonly use the term peripheral vascular disease to refer to peripheral artery disease (peripheral arterial disease, PAD), a condition that develops when the arteries that supply blood to the internal organs, arms, and legs become completely or partially blocked as a result of atherosclerosis.
- Peyronie's Disease (Curvature of the Penis) Peyronie's disease or curvature of the penis (Peyronie disease) is a condition in which scar tissue develops inside the penis. This scar tissue causes the penis to develop an abnormal curvature in the scarred area. At this time, there is no known cause of Peyronie's disease. Symptoms of Peyronie's disease include pain during intercourse or ejacul*tion, erectile dysfunction (ED, impotence), the inability to have sexual intercourse, anxiety, stress, an indentation of the shaft at the site where there is plaque or scarring, and an angulation of the penis when erect or flaccid. There is no cure for Peyronie's disease, however, there are medications that can reduce symptoms of the disease. Surgery or penile implants may be an option for severe cases.
- Claudication Claudication is lower leg pain and/or cramping due to limited blood flow and lack of oxygen as a result of hardened or blocked arteries (atherosclerosis). Peripheral artery disease (PAD) is the most common cause. Learn more about other causes, symptoms, and how to treat claudication.
Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
See more info: pentoxifylline on RxList
References
Medically reviewed by John P. Cunha, DO, FACOEP; Board Certified Emergency Medicine
REFERENCE:
FDA Prescribing Information